![]() All rights reserved.Ĭhanges in Body Temperature and Body Weight Following SARS-CoV-2 Infection in Phodopus Hamsters (A–C) Temperature changes of (A) Roborovski dwarf hamsters, (B) Campbell’s dwarf hamsters, and (C) Djungarian hamsters over the course of infection (shown as means with SD of at least 12, 7, and 6 animals per group). Based on our findings, we propose the Roborovski dwarf hamster as a valuable model to examine the efficacy and safety of vaccine candidates and therapeutics, particularly for use in highly susceptible individuals.ĬOVID-19 Campbell’s dwarf hamster (Phodopus campbelli) Djungarian hamster (Phodopus sungorus) Roborovski dwarf hamster (Phodopus roborovskii) animal model coronavirus histopathology pneumonia thrombosis.Ĭopyright © 2020 The Author(s). Particularly, only this species shows SARS-CoV-2-induced severe acute diffuse alveolar damage and hyaline microthrombi in the lungs, changes described in patients who succumbed to the infection but not reproduced in any experimentally infected animal. roborovskii) as a highly susceptible COVID-19 model with consistent and fulminant clinical signs. ![]() Here, we compare the susceptibilities of three dwarf hamster species (Phodopus spp.) to SARS-CoV-2 and introduce the Roborovski dwarf hamster (P. Different mammals are susceptible to SARS-CoV-2 however, few species examined so far develop robust clinical disease that mirrors severe human cases or allows testing of vaccines and drugs under conditions of severe disease. The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has precipitated an unprecedented and yet-unresolved health crisis worldwide.
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